Modeling and inference of genomic signatures of polygenic selection driving fast adaptation
STE 325/17-2
In fast adaptation, polygenic selection may be more important than selection on single genes. The goal of this project is to analyze a mathematical model of a quantitative trait that is subject to a combination of directional and stabilizing selection, mutation, and random genetic drift. In the first funding period, we have shown that for very large population sizes this model predicts two qualitatively different modes of fast polygenic adaptation: selective sweeps whereby large shifts in the allele frequencies occur at a few major loci and evolution via small changes in the allele frequencies at many minor loci. Here we study the influence of random genetic drift in finite populations (that may be subject to size changes). Furthermore, we develop methods to detect genomic signals of fast polygenic adaptation at mostly minor loci. Finally, we extend our original one-trait model by allowing polygenic selection on multiple traits (pleiotropy).
Publications
- Stephan, W. and A. Tellier (2020) Stochastic processes and host-parasite coevolution: linking coevolutionary dynamics and DNA polymorphism data. Probabilistic Structures in Evolution (E. Baake and A. Wakolbinger, eds.), European Mathematical Society Series of Congress Reports, in press
- Wolfgang Stephan and Sona John (2020) Polygenic Adaptation in a Population of Finite Size. Entropy 2020, 22(8), 907. DOI: 10.3390/e22080907
- John, S. and W. Stephan (2020) Important role of genetic drift in rapid polygenic adaptation. Ecology and Evolution DOI: 10.1002/ece3.5981
- Daniel Živković, Sona John, Mélissa Verin, Wolfgang Stephan, Aurélien Tellier (2019) Neutral genomic signatures of host-parasite coevolution. BMC Evol Biol 19, 230. DOI: 10.1186/s12862-019-1556-3
- Feurtey, A., D. Stevens, W. Stephan, and E. H. Stukenbrock (2019) Interspecific gene exchange introduces high genetic variability in crop pathogen. Genome Biol. Evol. 11: 3095-3105. DOI: 10.1093/gbe/evz224
- Stephan, W. (2019) Selective sweeps. Genetics 211: 5-13. DOI:
- Eldon B., Stephan W. (2018) Evolution of highly fecund haploid populations. Theoretical Population Biology. DOI: 10.1016/j.tpb.2017.10.002
- Kavita Jain, Wolfgang Stephan (2017) Modes of Rapid Polygenic Adaptation. Molecular Biology and Evolution 34(12):3169–3175. DOI: 10.1093/molbev/msx240
- Jain, K. and W. Stephan (2017) Rapid adaptation of a polygenic trait after a sudden environmental shift. Genetics 206: 389-406. DOI:
- Bozicevic, V., S. Hutter, W. Stephan, and A. Wollstein (2016) Population genetic evidence for cold adaptation in European Drosophila melanogaster populations. Mol. Ecol. 25: 1175-1191. DOI: 10.1111/mec.13464
- Stephan, W. (2016) Signatures of positive selection: from selective sweeps at individual loci to subtle allele frequency changes in polygenic adaptation. Mol. Ecol. 25: 79-88. DOI: 10.1111/mec.13288
- Jain, K. and W. Stephan (2015) Response of polygenic traits under stabilizing selection and mutation when loci have unequal effects. G3-Genes Genomes Genetics 5: 1065-1074. DOI: